The Participating Institutions engaged in a particular research study determine which IRB will provide the review. If a Participating Institution involved in the research disagrees with the selection of IRB, that institution, unless prohibited by applicable policy (e.g., NIH Single IRB Policy) or obligation (e.g., terms of participation in a consortium), may decline to cede review to that IRB and may use its own IRB (if applicable) or agree that the IRB of another Participating Institution will provide review on its behalf (unless ceding review to a particular IRB is a requirement of study participation). This may result in more than one IRB providing review for a given research study.
A Reviewing IRB is usually identified in one of the following ways:
- Pre-determined by the study sponsor or grant.
- Established by prior arrangement (e.g. network central IRB).
- IRB from Overall PI’s institution.
- Selected based on expertise in the study area (e.g. type of procedures to be performed or subject population).