Is the IRB at the Overall PI’s institution required to be the Reviewing IRB for a study proposed by that PI?

No, the IRB at the Overall PI’s institution is not required to be the Reviewing IRB for that study. However, the Overall PI’s home IRB has the right of first refusal to serve as the Reviewing IRB and will typically be identified as the Reviewing IRB by default, unless another Reviewing IRB has already been pre-determined by a study sponsor or grant, the Reviewing IRB has already been established by prior arrangement (e.g., a network central IRB), or an IRB is determined to be a more appropriate Reviewing IRB for a particular study (e.g., based on type of procedures to be performed, subject population, or other criteria).