When submitting a request for reliance, the submitter (the Overall Principal Investigator or designee) requests a specific Reviewing IRB on the request form.
Once the request has been submitted, the Overall PI’s home institution first reviews the request to determine whether the study is eligible for reliance; if so, that institution is then given the first option to serve as the Reviewing IRB. If the Overall PI's home institution declines or is unable to serve as the Reviewing IRB, that institution’s Reliance POC or Reliance POC Backup(s) have the responsibility to propose a Reviewing IRB in the System, and may take the investigator’s request into consideration in doing so.
After an institution indicates willingness to be the proposed Reviewing IRB, the other engaged site(s) will have the opportunity to indicate their willingness to rely upon that IRB for review and oversight of the research.
Overview of the reliance request and decision-making processes
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